When you place bacteria on a graphene sheet, they scrape out a single, detectable cylinder. This provides opportunities!

Imagine if you heard bacteria. Then after a successful course of antibiotics, it will be completely calm. And if treatment doesn’t work, it’s still noisy. Unfortunately, bacteria do not reveal their potential antibiotic resistance in this way; They are not troublemakers after all. although; in the paper Nature’s nanotechnology Dutch researchers recently announced that they have successfully eavesdropped on a single bacterium.

How do?
The researchers used graphene sheets for this. “Graphene is a form of carbon made up of a single layer of atoms and is known as the wonder material,” explains researcher Farbod Allejani. “It is very strong, has good electrical and mechanical properties, and is very sensitive to external forces.”

The latter also became apparent when the researchers placed bacteria on a graphene sheet. “When a single bacteria sticks to the graphene sheet (which actually acts as a kind of sensor), that sheet vibrates with an amplitude of a few nanometers,” says Alijani. Scientias. nl† “And we can detect these vibrations with laser light.” “We can hear the sound of a single bacterium!” Adds nanobiologist and co-author Ces Decker.

According to Eligani, the vibrations, or sound produced by bacteria attached to the graphene sheet, are primarily caused by the flagella. They are tails on the surface of the cell that bacteria move through. The flagellum acts as a kind of drumstick, with the graphene skin being actually the drum assembly. “To understand how small these whip strikes on graphene are, you can say that they are at least 10 billion times smaller than a boxer’s punch on a punching bag,” Alijani said. “However, these nano-tones can be converted into audio tracks and listened to – and how cool is that?”

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coli bacteria
The researchers worked in their experiments with known bacteria Escherichia coli (in short coli bacteria† †coli bacteria They are the model bacteria for biophysical research and that’s what we started with,” says Alijani. “But we have now expanded our experiments to include other bacteria, including Pseudomonas and Klebsiella.” The results of those studies—in contrast to the study with coli bacteria – Not yet published.

It is easy to explain that researchers are now also looking at other bacteria; experiments with coli bacteria A hint to an interesting application of graphene. For example, the “wonderful substance” can also be used to combat antibiotic resistance. Experiments have shown that non-resistant bacteria treated with antibiotics on graphene paper stop rapidly; The tremors subsided for an hour or two, to disappear completely. It was very different for the resistant bacteria on the graphene plate when they were exposed to antibiotics. Keep the tabla at the same level. “The main application of our study is to develop a new generation of tests that can determine the sensitivity of bacterial infections to antibiotics,” Alijani said. “Current tests often take a long time (at least 24 to 48 hours and sometimes – depending on the formation time of the bacteria – even longer). Our technology shows that graphene can demonstrate the effectiveness of antibiotics in as little as 1-2 hours, reducing the time it takes Diagnosing antibiotic resistance from days to hours.